Fixed-interval schedules for drug self-administration in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1989 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 99, pages 136-139 (issn: 0033-3158, eissn: 1432-2072,

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Authors: W A, Corrigall; K M, Coen;

doi: 10.1007/bf00634468

pmid: 2506599

Fixed-interval schedules for drug self-administration in the rat

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Abstract

The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates comparable to those obtained with cocaine or food as reinforcer.

Related Organizations

Addiction Research Foundation
United States
University of Toronto
Canada

Keywords

Heroin, Male, Reinforcement Schedule, Cocaine, Dose-Response Relationship, Drug, Animals, Self Administration, Rats

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