Degradation of hypothalamic hormones

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1977 English Publisher:Springer Science and Business Media LLCJournal:Naunyn-Schmiedebergs Archives of Pharmacology, volume 297, pages S55-S56 (issn: 0028-1298, eissn: 1432-1912,

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Authors: K, Bauer;

doi: 10.1007/bf00587778

pmid: 404575

Degradation of hypothalamic hormones

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Abstract

The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed primary fragments.

Related Organizations

Technical University of Berlin
Germany
Technical University of Berlin
Germany

Keywords

Hydrolysis, Pituitary Gland, Hypothalamus, Animals, Thyrotropin-Releasing Hormone, Rats

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