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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Pflügers Archiv - Eu...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Pflügers Archiv - European Journal of Physiology
Article . 1977 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
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Hypothalamic control of plasma renin activity

Authors: A. Logofetov; N. Tzaneva; N. Natcheff;

Hypothalamic control of plasma renin activity

Abstract

The participation of the hypothalamus in the regulation of plasma renin activity (PRA) in rats was studied by applying electric stimulation to the supramammilar region (50 Hz, 1 ms, 150 muA), general hypoxia (90% N2 + 10% O2), and hypovolemia (peritoneal dialysis with 5.5% glucose) as stimuli of renin secretion. These techniques were combined with bilateral renal denervation and electrocoagulation in the supramammilar nuclei. PRA was determined by means of RIA (Radioimmunoassay) for AI with 2-h incubation. Our investigations showed that: 1. Electric stimulation, hypoxia and hypovolemia cause an increase of PRA against the controls by 127%, 465% and 197%, respectively. 2. After electrocoagulation the hypoxic stimulus remains ineffective, whereas hypovolemia is manifested. 3. Electric stimulation in rats with denervated kidneys produces no effect. These results suggested that: a) Diminution of the extracellular volume, without hypoxia, is in itself a powerful stimulus of renin secretion. b) The posterior hypothalamus is closely connected with the regulation of PRA as an obligatory unlocking link of the reaction by the organism to general hypoxic stimuli. The control function of the hypothalamus is realized in this case by means of the sympathetic part of the vegetative nervous system.

Keywords

Hypothalamus, Posterior, Hypothalamus, Kidney, Denervation, Electric Stimulation, Rats, Renin, Animals, Hypoxia, Peritoneal Dialysis

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Average
Top 10%
Average
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