The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxylmethyl]-2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 62, pages 220-223 (issn: 0340-5761, eissn: 1432-0738,

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Authors: J G, Clement; P A, Lockwood; H G, Thompson;

doi: 10.1007/bf00570144

pmid: 3196157

The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxylmethyl]-2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources

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Abstract

A comparison of the chemical purity, toxicology and potency of HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2- [(hydroxyimino)methyl]-pyridinium dichloride) obtained from various sources (Canada, Israel, Yugoslavia, The Netherlands, United Kingdom) was performed. There were no significant differences between HI-6 obtained from Israel, Yugoslavia, The Netherlands and Canada regarding their potency, when combined with atropine, as an antidote of organophosphate poisoning. HI-6 obtained from the United Kingdom was significantly more toxic and less potent than any of the other HI-6 samples. In addition, the results of this study showed that there was no significant difference between HI-6 prepared as a laboratory batch and HI-6 prepared commercially with regards to chemical purity, toxicology or potency.

Keywords

Lethal Dose 50, Male, Cholinesterase Reactivators, Mice, Oximes, Animals, Female, Pyridinium Compounds, Drug Contamination

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