The biological activity of mangiferin makes the search for sources of natural raw material for its isolation urgent [3], and the distribution of the xanthones in higher plants is of interest for the purposes of chemosystematics [6]. All this could not but draw our attention to this group of compounds, since a large number of xanthones has been detected in representatives of the family Guttiferae. In the most numerous genus Hype~c~ L., maculatoxanthone has been found, having been isolated from H. maculatum Cranz [7], and the presence of mangiferin in H. h~fus~ L. has been established chromatographically [8]. When 12 species of the genus Hype~c~ growing in the territory of the People's Republic of Bulgaria were investigated, mangiferin was detected in four species, being present in largest amount in the herb H. auche~i Jaub. et Spach. • Mangiferin was isolated from the epigeal part of H. auohe~i collected in the flowering period of the Eastern Rhodopes mountains. The raw material was treated with chloroform to eliminate ballast substances, and the combined phenolic substances were extracted with 95%, and then with 70%, ethanol. The ethanolic extracts were concentrated and were additionally purified with chloroform. The purified extract was repeatedly treated with ethyl acetate. The solvent was distilled off, and the residue was dissolved in 80% ethanol. The precipitate that deposited after cooling was recrystallized from 80% ethanol. The yield of mangiferin from air-dry raw material was 0.1%. %CH30H 242, 258, 317, The substance obtained, C19H180:I, had mp 264-266°C (decomp.); max