An improved method for butyrylcholinesterase phenotyping

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1994 English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 32, pages 83-89 (issn: 0006-2928, eissn: 1573-4927,

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Authors: G, Picheth; C, Fadel-Picheth; S L, Primo-Parmo; E A, Chautard-Freire-Maia; M M, Vieira;

doi: 10.1007/bf00554417

pmid: 7980387

An improved method for butyrylcholinesterase phenotyping

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Abstract

An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses alpha-naphthyl acetate as substrate and DL-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested (BCHE U, BCHE UF, BCHE UA, BCHE AK, BCHE AF, and BCHE A). These modifications make the method even more adequate for population studies and clinical routine.

Related Organizations

State University of West Paraná
Brazil

Keywords

Quaternary Ammonium Compounds, Naphthol AS D Esterase, Phenotype, Butyrylcholinesterase, Humans, Cholinesterase Inhibitors, Propranolol, Alleles

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