Cadmium metabolism in cdm/cdm mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1979 United States English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 17, pages 731-736 (issn: 0006-2928, eissn: 1573-4927,

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Authors: Orlowski, Craig; Bloor, John H.; Meisler, Miriam H.; Gross, Ellen;

doi: 10.1007/bf00502131

pmid: 540016

handle: 2027.42/44133

Cadmium metabolism in cdm/cdm mice

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Abstract

The uptake and metabolism of cadmium by cadmium-susceptible (+/+) and cadmium-resistant (cdm/cdm) strains of mice have been compared. These strains did not differ with respect to the quantitative uptake of cadmium into liver, kidney, or testis. After intraperitoneal administration of a nontoxic dose, more than 80% of the cadmium in liver and testis of both strains is bound to low molecular weight proteins. The chromatographic behavior of these cadmium-binding proteins is not affected by cdm genotype.

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United States

Related Organizations

Jackson Laboratory
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University of Michigan–Flint
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State University of New York at Potsdam
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University at Buffalo, State University of New York
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University of Michigan–Ann Arbor
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Keywords

Male, Genotype, Science, Ecology and Evolutionary Biology, Genetic Susceptibility, Kidney, Biochemistry, Mice, Strains:, Metabolism:, Health Sciences, Testis, Animals, Cellular and Developmental Biology, General, Genes:, Molecular, Natural Resources and Environment, Human Genetics, Mice, Mutant Strains, Biomedicine, Liver, Medical Microbiology, Metallothionein, Hereditary Factors:, Carrier Proteins, Zoology, Cadmium

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