A method for investigation of enterohepatic circulation

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1972 English Publisher:Springer Science and Business Media LLCJournal:Naunyn-Schmiedeberg's Archives of Pharmacology, volume 274, pages 208-210 (issn: 0028-1298, eissn: 1432-1912,

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Authors: N, Rietbrock; U, Abshagen;

doi: 10.1007/bf00501857

pmid: 4262280

A method for investigation of enterohepatic circulation

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Abstract

A method is described for simultaneous determination of a drug and its metabolites in blood and bile of rats with intact enterohepatic circulation. The comparison with the respective data obtained in biliary fistula animals allows a statement on enterohepatic circulation of the drug, if the bile flow is identical in both groups.

Related Organizations

Humboldt-Universität zu Berlin
Germany

Keywords

Digoxin, Biliary Fistula, Rats, Inbred Strains, Rats, Cardiac Glycosides, Intestines, Kinetics, Intestinal Absorption, Liver, Regional Blood Flow, Methods, Animals, Bile, Female, Liver Circulation

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