Receptor desensitization by lobeline and nicotine

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1973 English Publisher:Springer Science and Business Media LLCJournal:Naunyn-Schmiedeberg's Archives of Pharmacology, volume 276, pages 49-54 (issn: 0028-1298, eissn: 1432-1912,

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Authors: R L, Volle; L, Reynolds;

doi: 10.1007/bf00500777

pmid: 4266250

Receptor desensitization by lobeline and nicotine

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Abstract

In frog sartorius muscles, lobeline had no effect on resting membrane potentials but prevented depolarization of the fibers by nicotine. The blockade caused by lobeline was not antagonized by elevated concentrations of nicotine. Procedures that prevented depolarization of the fibers by nicotine had no effect on the anti-nicotinic effects of nicotine. It was concluded that receptor desensitization in skeletal muscle does not require depolarization of the fibers.

Related Organizations

University of Connecticut Health Center
United States

Keywords

Nicotine, Sensory Receptor Cells, Muscles, Rana pipiens, In Vitro Techniques, Membrane Potentials, Desensitization, Immunologic, Neuromuscular Depolarizing Agents, Animals, Lobeline, Anura

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