On the similarity of tetanus and botulinum toxins

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1973 English Publisher:Springer Science and Business Media LLCJournal:Naunyn-Schmiedeberg's Archives of Pharmacology, volume 276, pages 303-310 (issn: 0028-1298, eissn: 1432-1912,

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Authors: J, Mellanby; P A, Thompson; N, Hampden;

doi: 10.1007/bf00499884

pmid: 4268161

On the similarity of tetanus and botulinum toxins

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Abstract

1. Botulinum toxin blocks neuromuscular transmission to the abductor superficialis muscle of the goldfish pectoral fin. Since the botulinum-paralysed muscles are still responsive to direct electrical stimulation and to carbachol it is probable that the toxin acts (at least partly) presynaptically. The actions of botulinum and tetanus toxins at this site are similar. 2. Tetanus toxin is fixed by nervous tissue and this fixation is due to gangliosides, in particular to those gangliosides containing two sialic acid residues joined to each other by a sialidase-sensitive bond. In contrast, botulinum toxin is not fixed by either nervous tissue or by gangliosides. 3. The implication of these findings for the role of the fixation of tetanus toxin by ganglioside in the mode of action of tetanus toxin are discussed.

Related Organizations

University of Oxford
United Kingdom

Keywords

Binding Sites, Botulinum Toxins, Muscles, Cyprinidae, Neuromuscular Junction, Brain, Nerve Tissue Proteins, Electric Stimulation, Mice, Tetanus Toxin, Gangliosides, Animals, Paralysis, Carbachol, Cattle, Chromatography, Thin Layer, Protein Binding

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