
doi: 10.1007/bf00498924
pmid: 6626146
In an assay measuring radioactive incorporation from gamma--P32P]ATP into phosphorylase b, cardiac muscle extracts from mice with the phosphorylase kinase deficiency mutation showed significant, calcium-dependent phosphorylase kinase activity that was 10 to 15% of that of Swiss mice, the control strain. Isoproterenol stimulated significant phosphorylase a accumulation in both isolated atria and right ventricular strips of phosphorylase kinase-deficient mice, and the drug-stimulated increases in phosphorylase a activity the the contractile responses of right ventricular strips were similar in Swiss and phosphorylase kinase/deficient mice.
Male, Mice, Phosphorylase Kinase, Myocardium, Mutation, Isoproterenol, Animals, Phosphorylase a, In Vitro Techniques, Myocardial Contraction
Male, Mice, Phosphorylase Kinase, Myocardium, Mutation, Isoproterenol, Animals, Phosphorylase a, In Vitro Techniques, Myocardial Contraction
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