Vernolepin: An antiplatelet compound of natural origin
Copyright policy )Vernolepin: An antiplatelet compound of natural origin
Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a "stabilizing" effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1 X 10(-5) g/ml seems to be optimal.
- University of Antwerp Belgium
- Janssen (Belgium) Belgium
- Janssen Pharmaceutica Belgium
Blood Platelets, Arachidonic Acid, Time Factors, Platelet Aggregation, Pharmacology. Therapy, Arachidonic Acids, In Vitro Techniques, Adenosine Diphosphate, Microscopy, Electron, Adenosine Triphosphate, Glutaral, Freezing, Animals, Collagen, Rabbits, Sesquiterpenes
Blood Platelets, Arachidonic Acid, Time Factors, Platelet Aggregation, Pharmacology. Therapy, Arachidonic Acids, In Vitro Techniques, Adenosine Diphosphate, Microscopy, Electron, Adenosine Triphosphate, Glutaral, Freezing, Animals, Collagen, Rabbits, Sesquiterpenes
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