
doi: 10.1007/bf00486412
pmid: 4210301
Individuals of an alcohol dehydrogenase-negative strain of Drosophila melanogaster designated Adh n5 are resistant to ethanol poisoning at low but not at high temperatures. The basis for this behavior is that Adh n5 flies contain a mutant form of alcohol dehydrogenase which is less heat stable than that of wild-type flies. The mutation in Adh n5 maps at, or very close to, the presumptive structural locus and is not complemented by any of 11 other alcohol dehydrogenase-null mutants.
Aging, Hot Temperature, Time Factors, Ethanol, Homozygote, Temperature, Chromosome Mapping, Hydrogen-Ion Concentration, Alcohol Oxidoreductases, Kinetics, Drosophila melanogaster, Drug Stability, Genes, Species Specificity, Mutation, Animals
Aging, Hot Temperature, Time Factors, Ethanol, Homozygote, Temperature, Chromosome Mapping, Hydrogen-Ion Concentration, Alcohol Oxidoreductases, Kinetics, Drosophila melanogaster, Drug Stability, Genes, Species Specificity, Mutation, Animals
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