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Glutamate oxalate transaminase (GOT) genetics in Mus musculus: Linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1970 English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 4, pages 259-273 (issn: 0006-2928, eissn: 1573-4927,

Authors: Robert J. DeLorenzo; Frank H. Ruddle;

doi: 10.1007/bf00485777

pmid: 4193185

Glutamate oxalate transaminase (GOT) genetics in Mus musculus: Linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci

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Abstract

A comparison of electrophoretic patterns of F1 and backcross progeny of two inbred strains of mice has revealed a new autosomal variant of the mitochondrial form of GOT. The loci controlling the production of the soluble and mitochondrial forms of GOT have been designated Got-1 and Got-2, respectively. The two alleles of the Got-2 locus have been designated Got-2 a and Got-2 b, which represent the slow- and fast-migrating electrophoretic forms. Twenty-seven inbred strains of mice have been classified for Got-2 a and Got-2 b. It has been demonstrated that the polymorphism of Got-2 is widely distributed in feral mice. Got-2 was shown to be linked to Es-1, and evidence is also presented for linkage between Got-2 and Es-2, Es-5, and oligosyndactyly (Os). The absence of linkage of Got-2 to seven other loci has also been demonstrated. GOT was expressed in vitro in cell lines derived from human and mouse tissues.

Related Organizations

Yale University
United States

Keywords

Chromosome Aberrations, Electrophoresis, Immunodiffusion, L-Lactate Dehydrogenase, Genetic Linkage, Esterases, Chromosome Mapping, Centrifugation, Mitochondria, Liver, Glucosephosphate Dehydrogenase, Mitochondria, Isoenzymes, Mice, Phenotype, Phosphoglucomutase, Malate Dehydrogenase, Animals, Aspartate Aminotransferases, Molecular Biology, Alleles

4 Research products, page 1 of 1

Aspartate aminotransferase, mitochondrial
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Aspartate aminotransferase, cytoplasmic
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