Expression of the human adenylate kinase isozymes, phosphopyruvate hydratase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase-1 in man-rodent somatic cell hybrids

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1976 English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 14, pages 1-17 (issn: 0006-2928, eissn: 1573-4927,

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Authors: G A, Bruns; P S, Gerald;

doi: 10.1007/bf00484869

pmid: 176998

Expression of the human adenylate kinase isozymes, phosphopyruvate hydratase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase-1 in man-rodent somatic cell hybrids

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Abstract

The expression of the adenylate kinase isozymes and of phosphopyruvate hydratase was studied in man-mouse and man-hamster hybrid clones. Concordant segregation of the loci coding for AK-2 and PPH was observed in 54 of 55 primary hybrid clones, and these loci were demonstrated to be synthetic with the loci specifying PGM-1 and PGD. The pattern of expression of the four enzymes in discordant clone suggests the gene order 1pter-(PGD, PPH)-AK-2-PGM-1-centromere. In addition, AK-1 was found to be expressed independently of AK-2.

Related Organizations

Children's Hospital & Medical Center
United States
Harvard University
United States

Keywords

Male, Phosphogluconate Dehydrogenase, Adenylate Kinase, Phosphotransferases, Hybrid Cells, Chromosomes, Translocation, Genetic, Clone Cells, Isoenzymes, Mice, Phosphoglucomutase, Phosphopyruvate Hydratase, Animals, Humans, Female

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