The plasma protein binding of HIDA
Copyright policy )The plasma protein binding of HIDA
By using Sephadex gel column chromatography to separate substances into their various components according to molecular weight, we have investigated the effect of incubating several "brands" of HIDA in plasma, in vitro. The results show that such incubation has no effect on either dimethyl HIDA, or diethyl HIDA, but that in the case of para-butyl HIDA, incubation in plasma increases the Rf value to that of HSA (human serum albumin). This indicates that para-butyl HIDA becomes bound to plasma proteins, in contrast to both dimethyl HIDA and diethyl HIDA.
- Manchester Royal Infirmary United Kingdom
Imino Acids, Technetium, Technetium Tc 99m Lidofenin, Blood Proteins, Organotechnetium Compounds, In Vitro Techniques, Technetium Tc 99m Diethyl-iminodiacetic Acid, Italy, Humans, Reagent Kits, Diagnostic, Switzerland, Protein Binding
Imino Acids, Technetium, Technetium Tc 99m Lidofenin, Blood Proteins, Organotechnetium Compounds, In Vitro Techniques, Technetium Tc 99m Diethyl-iminodiacetic Acid, Italy, Humans, Reagent Kits, Diagnostic, Switzerland, Protein Binding
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