Skin test-active substance prepared from culture filtrate of Fonsecaea pedrosoi
Copyright policy )Skin test-active substance prepared from culture filtrate of Fonsecaea pedrosoi
Ethanol-precipitated substance (EP) was prepared from culture filtrate of Fonsecaea pedrosoi. EP was separated into two components by passing through a Sephadex G-50 column; the faster passing component was referred to as EP-1, the slower as EP-2. EP-1 and EP-2 were evaluated as an antigen for detecting cutaneous delayed hypersensitivity in patients with chromomycosis. EP-1 elicited positive delayed skin reactions in all of 8 patients with chromomycosis, of which 7 caused by F. pedrosoi and one by Exophiala jeunselmei. Healthy subjects, patients with sporotrichosis and patients with tinea barbae failed to react to EP-1. These results indicate that EP-1 is a useful tool for detecting cutaneous delayed hypersensitivity in patients with chromomycosis caused by F. pedrosoi. It was found that precipitin test using EP-1 as an antigen had little diagnostic value in chromomycosis. EP-2 did not show antigenic activity in both skin and precipitin reactions.
- Chiba University Japan
Adult, Male, Antigens, Fungal, Chromoblastomycosis, Middle Aged, Precipitin Tests, Diagnosis, Differential, Humans, Female, Hypersensitivity, Delayed, Mitosporic Fungi, Aged, Skin Tests
Adult, Male, Antigens, Fungal, Chromoblastomycosis, Middle Aged, Precipitin Tests, Diagnosis, Differential, Humans, Female, Hypersensitivity, Delayed, Mitosporic Fungi, Aged, Skin Tests
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