The complete set of enzymes that catalyze the reactions from l-phenylalanine to substituted cinnamyl alcohols is now known. The latter compounds are the primary building stones of lignin. The individual reactions and the possible modes of regulation of this pathway are discussed. The polymerization of cinnamyl alcohols to lignin is mediated by peroxidase. The significance of cell-wall-bound peroxidases in this process and the origin of hydrogen peroxide are reviewed. Finally, the possible role of lignification in relation to disease resistance is discussed.