Passive immunization in murine mucormycosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1983 English Publisher:Springer Science and Business Media LLCJournal:Mycopathologia, volume 83, pages 149-155 (issn: 0301-486X, eissn: 1573-0832,

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Authors: A R, Waldorf; C, Halde; N A, Vedros;

doi: 10.1007/bf00437021

pmid: 6669169

Passive immunization in murine mucormycosis

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Abstract

Antibody raised in mice against mycelial homogenates of Rhizomucor pusillus was effective in passive immunization against pulmonary and disseminated mucormycosis (phycomycosis) in immunocompromised mice. Mice intranasally inoculated and infected with Rh. pusillus and treated with antisera had a statistically significant increased resistance to infection and a diminished secondary dissemination of viable fungal fragments. Histological examination of infected lung tissues showed that antibody treated animals were apparently able to degrade hyphal fragments.

Related Organizations

University of California, Berkeley
United States
University of California, San Francisco
United States

Keywords

Mice, Immunization, Passive, Animals, Mucormycosis, Female, Lung

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