Effect of calcium on locomotor activity of mice

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1980 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 68, pages 207-208 (issn: 0033-3158, eissn: 1432-2072,

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Authors: Y K, Fung; N J, Uretsky;

doi: 10.1007/bf00432143

pmid: 6776568

Effect of calcium on locomotor activity of mice

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Abstract

Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.

Related Organizations

The Ohio State University
United States

Keywords

Male, Mice, Time Factors, Animals, Calcium, Motor Activity, Sleep, Pentobarbital, Postural Balance, Injections, Intraventricular

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