Modification of different morphine actions by 6-hydroxydopamine and 6-hydroxydopamine plus desmethylimipramine
Copyright policy )Modification of different morphine actions by 6-hydroxydopamine and 6-hydroxydopamine plus desmethylimipramine
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected. The concentration of 5-hydroxytryptamine (5-HT) is not influenced by 6-OHDA or 6-OHDA + DMI. Chronic morphine treatment to some extent enhances reduced NA and DA levels after 6-OHDA, but the decreased central catecholamine (CA) content after 6-OHDA + DMI is not raised. Morphine analgesia is highly attenuated in 6-OHDA and 6-OHDA + DMI mice. The reduction occurs in non-tolerant as well as in tolerant animals. The acute effect of morphine on body temperature is abolished with 6-OHDA, but not with 6-OHDA + DMI, whereas the interaction of central CA in morphine-induced running shows distinctly marked reduction with 6-OHDA + DMI, but not with 6-OHDA. Acute toxicity is enhanced by 6-OHDA + DMI whereas the development of tolerance against the toxicity of morphine is diminished by 6-OHDA. Lack of CA in the brain decreases sensitivity against naloxone withdrawal in acute as well as in chronic experiments.
- Humboldt-Universität zu Berlin Germany
Brain Chemistry, Male, Morphine, Desipramine, Motor Activity, Body Temperature, Hydroxydopamines, Mice, Animals, Humans, Drug Interactions, Analgesia, Morphine Dependence
Brain Chemistry, Male, Morphine, Desipramine, Motor Activity, Body Temperature, Hydroxydopamines, Mice, Animals, Humans, Drug Interactions, Analgesia, Morphine Dependence
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