Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man
Copyright policy )Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man
1. Five human subjects received intramuscularly at weekly intervals a placebo and equal doses of 6-hydroxy-N-dimethyltryptamine (6-HDMT) and N-dimethyltryptamine (DMT) (1 mg/kg, 4 subjects; 0.75 mg/kg, 1 subject). 2. DMT produced markedly significant mental effects including anxiety, hallucinations, and perceptual distortions and autonomic changes consisting of pupillary dilatation, increase in systolic and diastolic blood pressure, and a decrease in the kneejerk threshold. These effects appeared within 15–30 minutes and subsided within 1–2 hours. 3. The effects of 6-HDMT were not significantly different from those produced by a placebo.
- National Institutes of Health United States
- Emory Healthcare United States
- National Institute of Mental Health United States
- Addiction Research Center
- Saint Joseph's Hospital United States
Male, Indoles, Hallucinations, Anxiety, Toxicology, Anxiety Disorders, Placebos, Autonomic Nervous System Diseases, N,N-Dimethyltryptamine, Hallucinogens, Humans, Perception
Male, Indoles, Hallucinations, Anxiety, Toxicology, Anxiety Disorders, Placebos, Autonomic Nervous System Diseases, N,N-Dimethyltryptamine, Hallucinogens, Humans, Perception
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