The effect of nisin on murein synthesis
Copyright policy )The effect of nisin on murein synthesis
Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurHAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is not longer synthesized.
- Ludwig-Maximilians-Universität München Germany
- Bielefeld University Germany
Uridine Diphosphate N-Acetylglucosamine, Phosphotransferases, Magnesium, Peptidoglycan, Hydrogen-Ion Concentration, Nisin, Uridine Diphosphate N-Acetylmuramic Acid
Uridine Diphosphate N-Acetylglucosamine, Phosphotransferases, Magnesium, Peptidoglycan, Hydrogen-Ion Concentration, Nisin, Uridine Diphosphate N-Acetylmuramic Acid
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