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Propranolol and morphine

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1976 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 51, pages 39-42 (issn: 0033-3158, eissn: 1432-2072,

Authors: Anatole T. Zuban; German Navarro; Robert Richardson;

doi: 10.1007/bf00426318

pmid: 189341

Propranolol and morphine

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Abstract

The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done. Sotalol was used as a control drug to check which of the effects of propranolol could be regarded as due to beta blockade. Morphine LD50 in mice is not altered by pre-treatment with propranolol. The anticonvulsant characteristics of propranolol are different from those of sotalol, the former acting mainly on the tonic phase of the seizures. This study does not support the hypothesis that propranolol is a morphine antagonist but reinforces the idea that propranolol has definite central nervous system effects.

Related Organizations

University of California, Irvine
United States

Keywords

Lethal Dose 50, Male, Mice, Morphine, Seizures, Receptors, Adrenergic, beta, Sotalol, Animals, Propranolol

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