Effect of 6-hydroxydopamine on morphine analgesia

Name: Effect of 6-hydroxydopamine on morphine analgesia
Creator: I H, Ayhan
Keywords: Brain Chemistry, Male, 0301 basic medicine, 03 medical and health sciences, Catecholamines, 0302 clinical medicine, Morphine, Dopamine, Animals, Female

I H, Ayhan

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Psychopharmacologyarrow_drop_down

Psychopharmacology

Article . 1972 . Peer-reviewed

License: Springer TDM

Data sources: Crossref

https://pubmed.ncbi.nlm.nih.go...

Article . 1972

Data sources: Europe PubMed Central

https://dx.doi.org/10.1007/bf0...

Article

Data sources: Microsoft Academic Graph

Effect of 6-hydroxydopamine on morphine analgesia

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1972 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacologia, volume 25, pages 183-188 (issn: 0033-3158, eissn: 1432-2072,

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Authors: I H, Ayhan;

doi: 10.1007/bf00423196

pmid: 5048517

Effect of 6-hydroxydopamine on morphine analgesia

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Abstract

The influence of 6-OHDA on morphine analgesia estimated by the hot-plate method was investigated in rats. 6-OHDA injected intraventricularly at a dose of 250 Μg/rat, significantly and specifically depleted catecholamines from the brain. Morphine (7.5 mg/kg) produced a prominent analgesia in untreated and sham-injected rats whilst the reaction times of 6-OHDA pretreated rats did not change. When l-DOPA (50 mg/kg) was given to 6-OHDA pretreated rats, morphine recovered its analgesic action. These results suggest that catecholoamines play an important role in morphine analgesia.

Related Organizations

Ankara University
Turkey

Keywords

Brain Chemistry, Male, Catecholamines, Morphine, Dopamine, Animals, Female, Analgesia, Rats

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