Antipsychotic drugs stimulate prolactin release

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1974 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacologia, volume 40, pages 123-127 (issn: 0033-3158, eissn: 1432-2072,

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Authors: J A, Clemens; E B, Smalstig; B D, Sawyer;

doi: 10.1007/bf00421361

pmid: 4155803

Antipsychotic drugs stimulate prolactin release

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Abstract

Antipsychotic drugs have been found to markedly stimulate prolactin secretion in male and female rats. The amount of prolactin released was greater in females than in males. Most non-antipsychotic phenothiazines failed to alter prolactin. These results imply that the dopamine receptor that inhibits prolactin release may be similar to the dopamine receptor involved in the action of antipsychotic drugs.

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Eli Lilly (United States)
United States
Eli Lilly (India)
India

Keywords

Male, Chlorpromazine, Thioridazine, Dopamine, Receptors, Drug, Pimozide, Thiethylperazine, Promethazine, Stimulation, Chemical, Prolactin, Rats, Sex Factors, Tranquilizing Agents, Phenothiazines, Fluphenazine, Animals, Haloperidol, Female, Sulpiride

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