Two experiments addressed whether response latency in a trial of the lexical decision task is independent of the lexical status of the item presented in the previous trial. In Exp. 1, it was found that both word and nonword responses were significantly slower when the previous trial had involved a nonword than when it had involved a word. In Exp. 2, which employed a different list composition, it was found that responses to nonwords and pseudohomophones were significantly slower when the previous trial had involved a nonword or a pseudohomophone than when it had involved a word. However, responses to words were not influenced by the nature of the previous trial. We concluded that sequential dependencies exist across consecutive trials in the lexical decision task even when there is no semantic, morphological, phonological, or orthographic relationship between the items presented during those trials.