Cysteine proteinase inhibitors in psoriatic epidermis
Copyright policy )Cysteine proteinase inhibitors in psoriatic epidermis
Human psoriatic epidermis and scales were demonstrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7-5.0 (ACPI) and one neutral with an isoelectric point of 6.0-6.5 (NCPI), while normal epidermis contains only ACPI. The total papain (cysteine proteinase) inhibiting activity of the psoriatic epidermis as calculated per mg protein was higher than that in normal epidermis. Both ACPI and NCPI were localized immunocytochemically, mainly in the highest spinous cell layers with less activity in the parakeratotic cells and lower layers of spinous cells. Basal cells were essentially negative.
- Oulu University Hospital Finland
- University of Turku Finland
- University of Oulu Finland
Immunochemistry, Humans, Proteins, Psoriasis, Protease Inhibitors, Cysteine Proteinase Inhibitors, Epidermis
Immunochemistry, Humans, Proteins, Psoriasis, Protease Inhibitors, Cysteine Proteinase Inhibitors, Epidermis
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