descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1982 English Publisher:Springer Science and Business Media LLCJournal:Journal of Cancer Research and Clinical Oncology, volume 102, pages 227-233 (issn: 0171-5216, eissn: 1432-1335,

Authors: J. Althoff; U. Green;

doi: 10.1007/bf00411342

pmid: 7061570

Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters

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Abstract

Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.

Related Organizations

University of Hannover
Germany

Keywords

Male, Nitrosamines, Dose-Response Relationship, Drug, Mesocricetus, Digestive System Neoplasms, Respiratory Tract Neoplasms, Cricetinae, Carcinogens, Animals, Female

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