Morphine-withdrawal aggression: Sensitization by amphetamines

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1971 English Publisher:Springer Science and Business Media LLCJournal:Psychopharmacologia, volume 22, pages 217-223 (issn: 0033-3158, eissn: 1432-2072,

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Authors: H, Lal; J, O'Brien; S K, Puri;

doi: 10.1007/bf00401783

pmid: 5167207

Morphine-withdrawal aggression: Sensitization by amphetamines

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Abstract

Aggressive behaviors during the withdrawal from morphine sulfate (400 mg/kg/day), were potentiated by methylphenidate or d and l isomers of amphetamine. d-Amphetamine was most active, while hydroxyamphetamine was without any effect. Optimum effect of the drugs depended upon the drug dose and the time of morphine withdrawal.

Related Organizations

University of Rhode Island
United States

Keywords

Male, Dextroamphetamine, Time Factors, Morphine, Hydroxylamines, Rats, Substance Withdrawal Syndrome, Aggression, Amphetamine, Methylphenidate, Animals, Humans, Morphine Dependence

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