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Tolerance and cross-tolerance among psychotomimetic drugs

Name: Tolerance and cross-tolerance among psychotomimetic drugs
Keywords: Male, Amphetamine, Lysergic Acid Diethylamide, Mescaline, Milk, Behavior, Animal, Animals, Drug Tolerance, Reinforcement, Psychology, Injections, Intraperitoneal

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1968Publisher:Springer Science and Business Media LLCJournal:Psychopharmacologia, volume 13, pages 267-274 (issn: 0033-3158, eissn: 1432-2072,

Authors: James B. Appel; Daniel X. Freedman;

doi: 10.1007/bf00401404

pmid: 5679628

Tolerance and cross-tolerance among psychotomimetic drugs

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Abstract

A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance was also demonstrated.

Related Organizations

University of Chicago
United States

Keywords

Male, Amphetamine, Lysergic Acid Diethylamide, Mescaline, Milk, Behavior, Animal, Animals, Drug Tolerance, Reinforcement, Psychology, Injections, Intraperitoneal, Psilocybin, Rats

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	109
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%