Blood-cerebrospinal fluid barrier in schizophrenic patients

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jul 1987 English Publisher:Springer Science and Business Media LLCJournal:European Archives of Psychiatry and Neurological Sciences, volume 236, pages 257-259 (issn: 0175-758X, eissn: 1433-8491,

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Authors: K, Bauer; J, Kornhuber;

doi: 10.1007/bf00380949

pmid: 3653145

Blood-cerebrospinal fluid barrier in schizophrenic patients

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Abstract

A total of 15 young white male patients newly diagnosed as schizophrenic (DMS III) were examined for signs of blood-cerebrospinal fluid (CSF) barrier alteration and CNS IgG synthesis. Of the 15 patients, 8 exhibited signs of increased blood-CSF barrier permeability. There was a high correlation between the ratio for CSF/serum albumin concentration and the CSF total protein concentration. Local IgG synthesis in the CNS was not detected in any of the patients.

Related Organizations

University of Ulm
Germany

Keywords

Adult, Male, Blood-Brain Barrier, Immunoglobulin G, Schizophrenia, Humans, Cerebrospinal Fluid Proteins, Permeability, Serum Albumin

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