Mutagenicity tests with astemizole in vitro and in vivo

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1982 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 50, pages 167-173 (issn: 0340-5761, eissn: 1432-0738,

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Authors: P, Vanparys; L, Fabry; A, Léonard; R, Marsboom;

doi: 10.1007/bf00373399

pmid: 6812550

Mutagenicity tests with astemizole in vitro and in vivo

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Abstract

Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that is can be concluded that astemizole has no potential to induce chromosomal aberrations.

Related Organizations

Janssen Pharmaceutica
Belgium
Janssen (Belgium)
Belgium

Keywords

Cell Nucleus, Male, Mutagenicity Tests, Rats, Inbred Strains, Astemizole, Chromosomes, Rats, Liver, Animals, Humans, Benzimidazoles, Female, Genes, Lethal, Lymphocytes, Sister Chromatid Exchange, Cells, Cultured, Genes, Dominant, Subcellular Fractions

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