Centromere proteins
Copyright policy )Centromere proteins
Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr = 59,000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr = 59,000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis.
- Institute of Genetics Hungary
- MTA Biological Research Centre Hungary
- Hungarian Academy of Sciences Hungary
Centromere, Immunoblotting, Fluorescent Antibody Technique, Mitosis, Ribonuclease, Pancreatic, Fibroblasts, Precipitin Tests, Chromosomes, Mice, Animals, Deoxyribonuclease I, Humans, Electrophoresis, Polyacrylamide Gel, Cells, Cultured, Autoantibodies
Centromere, Immunoblotting, Fluorescent Antibody Technique, Mitosis, Ribonuclease, Pancreatic, Fibroblasts, Precipitin Tests, Chromosomes, Mice, Animals, Deoxyribonuclease I, Humans, Electrophoresis, Polyacrylamide Gel, Cells, Cultured, Autoantibodies
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