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Mammalian Genome
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Mammalian Genome
Article . 1995 . Peer-reviewed
License: Springer TDM
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Mammalian Genome
Article . 1995
Data sources: Europe PubMed Central
https://dx.doi.org/10.1007/bf0...
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University of Michigan: Deep Blue
Article . 1995
Data sources: Bielefeld Academic Search Engine (BASE)
https://dx.doi.org/10.1007/bf0...
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Localization of the murine cholecystokinin A and B receptor genes

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1995 United States English Publisher:Springer Science and Business Media LLCJournal:Mammalian Genome, volume 6, pages 242-246 (issn: 0938-8990, eissn: 1432-1777, Copyright policy )
Authors: Isakoff, M. S.; Lacourse, K. A.; Samuelson, Linda C.;

doi: 10.1007/bf00352408

pmid: 7613026

handle: 2027.42/47021

Localization of the murine cholecystokinin A and B receptor genes

Abstract

We have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus) F1 x Mus spretus. Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCKA and CCKB receptor cDNA probes. Unique map positions were determined by haplotype analysis with 650 previously mapped loci in the mouse backcross. The CCKA receptor gene (Cckar) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8. The CCKB receptor gene (Cckbr) mapped to mouse Chr 7, tightly linked to the beta-hemoglobin locus (Hbb). This localization places Cckbr in the same region as the mouse obesity mutation tubby (tub), which also maps near Hbb (2.4 +/- 1.4 cM). Since CCK can function as a satiety factor when administered to rodents, localization of Cckbr near the tub mutation identifies this receptor as a possible candidate gene for this obesity mutation.

Country
United States
Related Organizations
Keywords

Male, Genetic Linkage, Science, Ecology and Evolutionary Biology, Restriction Mapping, Chromosomes, Mice, Health Sciences, Animals, Obesity, Cellular and Developmental Biology, Crosses, Genetic, Life Sciences, Natural Resources and Environment, Molecular, Chromosome Mapping, Cell Biology, Receptor, Cholecystokinin B, Receptor, Cholecystokinin A, Mice, Inbred C57BL, Muridae, Blotting, Southern, Haplotypes, Mutation, Female, Receptors, Cholecystokinin, Anatomy, Zoology

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Average
Top 10%
Top 10%
bronze