Disruption of the 3′ phosphoglycerate kinase (pgk) gene in Aspergillus nidulans

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1993 English Publisher:Springer Science and Business Media LLCJournal:Current Genetics, volume 23, pages 123-128 (issn: 0172-8083, eissn: 1432-0983,

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Authors: S J, Streatfield; C F, Roberts;

doi: 10.1007/bf00352010

pmid: 8431952

Disruption of the 3′ phosphoglycerate kinase (pgk) gene in Aspergillus nidulans

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Abstract

We report the isolation of a pgk- mutant strain of Aspergillus nidulans by means of a gene disruption strategy, and demonstrate that the pgk gene is located on chromosome VIII. The pgk- mutant conidiates poorly, will only grow on media supplemented with both a glycolytic and a gluconeogenic carbon source, and is inhibited by hexoses.

Related Organizations

University of Leicester
United Kingdom

Keywords

Genes, Fungal, Genetic Vectors, Chromosome Mapping, Haploidy, Penicillium chrysogenum, Diploidy, Aspergillus nidulans, Phosphoglycerate Kinase, Phenotype, Transformation, Genetic, Mutation, Chromosomes, Fungal

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