The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1990 English Publisher:Frontiers Media SAJournal:Transplant International, volume 3, pages 23-25 (issn: 0934-0874, eissn: 1432-2277,

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Authors: Husberg, B. S.; Konrad, P. I.;

doi: 10.1007/bf00333198 , 10.1111/j.1432-2277.1990.tb01881.x

pmid: 2369477

The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats

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Abstract

Groups of isogenous Brown-Norway rats received heterotopic heart transplants from (Brown-Norway/Wistar Furth) x F1 hybrid rats. Methylprednisolone was administered IV in a daily dose of 5-40 mg/kg, using a dose interval of 24, 12, or 0 h (continuous infusion). Continuous infusion proved to be superior when small daily doses were used and then caused a more than threefold increase in graft survival. High daily doses created a substantial mortality with all dose intervals. Moreover, the equipment used for continuous drug administrations was unreliable beyond 4 weeks of infusion.

Related Organizations

Lund University
Sweden
Baylor University Medical Center
United States

Keywords

Immunosuppression Therapy, Male, Transplantation, Analysis of Variance, Dose-Response Relationship, Drug, Graft Survival, Methylprednisolone, Drug Administration Schedule, Rats, Transplantation, Isogeneic, Rats, Inbred BN, Animals, Heart Transplantation, Female

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