Genetic studies on temperature sensitive nonsense suppression

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1970 English Publisher:Springer Science and Business Media LLCJournal:Molecular and General Genetics MGG, volume 106, pages 362-370 (issn: 0026-8925, eissn: 1432-1874,

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Authors: E, Gallucci; G, Pacchetti; S, Zangrossi;

doi: 10.1007/bf00324053

pmid: 4921209

Genetic studies on temperature sensitive nonsense suppression

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Abstract

Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures. This temperature sensitivity is amenable to a reversible inactivation of the product of the su-4 gene.

Related Organizations

University of Milan
Italy

Keywords

Temperature, Chromosome Mapping, Alkaline Phosphatase, Coliphages, Suppression, Genetic, Genes, RNA, Transfer, Mutation, Escherichia coli, Tyrosine, Cell Division

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