Acrylamide and thiamine

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1989 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 63, pages 248-249 (issn: 0340-5761, eissn: 1432-0738,

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Authors: H, Igisu; I, Goto;

doi: 10.1007/bf00316377

pmid: 2764714

Acrylamide and thiamine

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Abstract

Acrylamide administration to rats caused clear alteration of blood thiamine content, which appeared to reflect suppressed intake and/or utilization of the vitamin in the body. Decreased utilization of thiamine does not seem to be induced by decreased binding of thiamine pyrophosphate (TPP) and apotransketolase, because acrylamide did not affect the Km of TPP for transketolase activity.

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Keywords

Brain Chemistry, Male, Acrylamides, Animals, Brain, Rats, Inbred Strains, Thiamine, Thiamine Pyrophosphate, Transketolase, Rats

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