Primidone and essential tremor

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988 English Publisher:Springer Science and Business Media LLCJournal:Journal of Neurology, volume 235, pages 168-170 (issn: 0340-5354, eissn: 1432-1459,

Copyright policy )

Authors: S, Seyfert; A, Honé; G, Holl;

doi: 10.1007/bf00314310

pmid: 3367165

Primidone and essential tremor

- Summary
- Subjects
- Metrics

Abstract

To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%-69% for up to 28 h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethyl-malonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor.

Related Organizations

Freie Universität Berlin
Germany

Keywords

Adult, Male, Phenobarbital, Tremor, Humans, Female, Phenylethylmalonamide, Middle Aged, Primidone, Aged

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	10
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average