Ganglioglioma with neurofibrillary tangles (NFTs): neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1995 English Publisher:Springer Science and Business Media LLCJournal:Acta Neuropathologica, volume 89, pages 451-453 (issn: 0001-6322, eissn: 1432-0533,

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Authors: D, Soffer; F, Umansky; J E, Goldman;

doi: 10.1007/bf00307651 , 10.1007/s004010050273

pmid: 7542425

Ganglioglioma with neurofibrillary tangles (NFTs): neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease

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Abstract

A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein, PHF/tau and ubiquitin. The demonstration in the neoplasm of abnormally phosphorylated and ubiquitinated cytoskeletal components, similar in morphology and in immunoreactivity to those seen in NFTs of Alzheimer's disease, suggest that similar pathogenetic mechanisms may operate in both conditions.

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Keywords

Adult, Male, Staining and Labeling, Brain Neoplasms, Neurofibrillary Tangles, tau Proteins, Immunohistochemistry, Epitopes, Alzheimer Disease, Neurofilament Proteins, Humans, Ubiquitins, Ganglioglioma

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