New gene in the homologous human 11q13?q14 and mouse 7F chromosomal regions

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 France English Publisher:Springer Science and Business Media LLCJournal:Mammalian Genome, volume 2, pages 195-200 (issn: 0938-8990, eissn: 1432-1777,

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Authors: Ollendorff, Vincent; Szepetowski, Pierre; Mattei, Marie-Geneviève; Gaudray, Patrick; Birnbaum, Daniel;

doi: 10.1007/bf00302877

pmid: 1543912

New gene in the homologous human 11q13?q14 and mouse 7F chromosomal regions

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Abstract

Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies in which most of the key genes remain to be identified. In an effort to isolate as many candidates as possible, we are cloning genes from this region. We report here the mapping of a new sequence from 11q13.5-11q14. This sequence, designated D11S833E, putatively encodes a new gene, provisionally named GARP. We cloned its homologous sequence in the mouse and located it on Chromosome (Chr) 7, region F. The human and mouse genes belong to a conserved group of synteny. This, together with the similar conservation of the FGF and TYR genes, indicates that the human 11q13-q14 and mouse 7E-7F regions share homology.

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Keywords

homologous sequence, similar conservation, homologous sequence;chromosomal region ;mouse gene ;similar conservation, [SDV]Life Sciences [q-bio], Chromosomes, Human, Pair 11, Chromosome Mapping, Nucleic Acid Hybridization, Blotting, Northern, Cosmids, [SDV] Life Sciences [q-bio], Mice, chromosomal region, mouse gene, Animals, Humans, Cloning, Molecular, DNA Probes

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