Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1986 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 58, pages 282-283 (issn: 0340-5761, eissn: 1432-0738,

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Authors: H, Peter; J G, Filser; L, von Szentpály; H J, Wiegand;

doi: 10.1007/bf00297122

pmid: 3718233

Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

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Abstract

Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

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Keywords

Male, Kinetics, Animals, Rats, Inbred Strains, Biotransformation, Chlorofluorocarbons, Methane, Rats

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