Reciprocal or nonreciprocal human chromosome translocations?
Copyright policy )Reciprocal or nonreciprocal human chromosome translocations?
Two carriers of a balanced translocation, one paternal t(9q-;13p+) and one maternal t(3q-;15p+), were studied cytogenetically with selective silver staining to localize more precisely the break points on the short arms of the two acrocentric chromosomes involved. The distal ends of both chromosomes 3 and 9 reacted positively to the selective silver staining. This observation allows the conclusion that the NOR (nucleolar organizer region), or parts of it, is in fact active in organizing nucleoli and by implication produces rRNA after the translocation onto chromosomes 3 and 9.
- Institut für Humangenetik Germany
- University of Göttingen Germany
Chromosomes, Human, 6-12 and X, Male, Silver, Staining and Labeling, Centromere, Chromosomes, Human, 1-3, Trisomy, Translocation, Genetic, RNA, Transfer, Humans, Female, Chromosomes, Human, 13-15
Chromosomes, Human, 6-12 and X, Male, Silver, Staining and Labeling, Centromere, Chromosomes, Human, 1-3, Trisomy, Translocation, Genetic, RNA, Transfer, Humans, Female, Chromosomes, Human, 13-15
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