Effect of nitrofurantoin on meiosis of the male mouse

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1977 English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 39, pages 345-351 (issn: 0340-6717, eissn: 1432-1203,

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Authors: C, Fonatsch;

doi: 10.1007/bf00295430

pmid: 598843

Effect of nitrofurantoin on meiosis of the male mouse

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Abstract

The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.

Related Organizations

Hochschule Hannover
Germany
Hannover Medical School
Germany

Keywords

Male, Meiosis, Mice, Nitrofurantoin, Spermatocytes, Animals

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