Synaptophysin expression in the striatum in Huntington's disease
Copyright policy )Synaptophysin expression in the striatum in Huntington's disease
This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.
- Montefiore Medical Center United States
Huntington Disease, Synaptophysin, Antibodies, Monoclonal, Humans, Membrane Proteins, Immunohistochemistry, Corpus Striatum
Huntington Disease, Synaptophysin, Antibodies, Monoclonal, Humans, Membrane Proteins, Immunohistochemistry, Corpus Striatum
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