Are pyrimidine dimers Non-Instructive lesions?

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1981 English Publisher:Springer Science and Business Media LLCJournal:Molecular and General Genetics MGG, volume 182, pages 511-513 (issn: 0026-8925, eissn: 1432-1874,

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Authors: C W, Lawrence;

doi: 10.1007/bf00293945

pmid: 7029214

Are pyrimidine dimers Non-Instructive lesions?

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Abstract

Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions.

Related Organizations

University of Rochester Medical Center
United States

Keywords

DNA, Bacterial, DNA Repair, Pyrimidine Dimers, Ultraviolet Rays, Mutation, Escherichia coli, Saccharomyces cerevisiae, DNA, Fungal

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