The insensitivity of Vinca rosea to vinblastine

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1977 English Publisher:Springer Science and Business Media LLCJournal:Chromosoma, volume 61, pages 277-287 (issn: 0009-5915, eissn: 1432-0886,

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Authors: M R, Kramers; H, Stebbings;

doi: 10.1007/bf00292811

pmid: 872704

The insensitivity of Vinca rosea to vinblastine

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Abstract

Root tip mitosis in both Vinca rosea and the chosen control Lepidium sativum is susceptible to the effects of colchicine at and above 5X10(-4)M.--Root tip mitosis in L. sativum is susceptible to the effects of vinblastine at concentrations equal to and greater than 10(-4)M, while root tip mitosis in V. rosea, the plant which is the source of vinblastine, is unaffected by exogenously-applied VBL at concentrations up to and including 10(-2)M.--The possible mechanisms by which the resistance of V. rosea to vinblastine might be conferred are discussed.

Related Organizations

University of Exeter
United Kingdom

Keywords

Plant Cells, Mitosis, Plants, Vinblastine

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