Multilocus analysis of the fragile X syndrome
Copyright policy )Multilocus analysis of the fragile X syndrome
A multilocus analysis of the fragile X (fra(X] syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).
- Greenwood Genetic Center United States
- Umeå University Sweden
- Mayo Clinic United States
- University of Rome Tor Vergata Italy
- Baylor College of Medicine United States
Genetic Markers, Male, Genetic Linkage, Chromosome Mapping, Genetic Variation, DNA, Pedigree, Settore MED/03, Fragile X Syndrome, Genetics, Humans, Genetics(clinical), Female, Sex Chromosome Aberrations, Software
Genetic Markers, Male, Genetic Linkage, Chromosome Mapping, Genetic Variation, DNA, Pedigree, Settore MED/03, Fragile X Syndrome, Genetics, Humans, Genetics(clinical), Female, Sex Chromosome Aberrations, Software
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