Genetic changes in mammalian cells reminiscent of an SOS response

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1984 Germany English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 67, pages 360-368 (issn: 0340-6717, eissn: 1432-1203,

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Authors: Herrlich, P.; Mallick, U.; Ponta, H.; Rahmsdorf, H. J.;

doi: 10.1007/bf00291392

pmid: 6092260

Genetic changes in mammalian cells reminiscent of an SOS response

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Abstract

Prior to the isolation of mammalian DNA repair genes and identification of their gene products, the comparison between the bacterial SOS response and various similar reactions in mammalian cells remains rather speculative. The increasing number of observed phenomena including enhanced DNA repair, virus induction, induced cellular differentiation, and neoplastic transformation, all following DNA damage or arrest of replication, are, however, suggestive of an SOS-like system of growth control and may form an entry into this fascinating area.

Country

Germany

Related Organizations

Karlsruhe Institute of Technology
Germany

Keywords

DNA Replication, DNA, Bacterial, 570, DNA Repair, Cell Survival, Simian virus 40, Cell Line, Escherichia coli, Animals, Humans, info:eu-repo/classification/ddc/570, biology, Gene Amplification, Cell Differentiation, DNA, Life sciences, Cell Transformation, Neoplastic, Phenotype, Gene Expression Regulation, Genes, Mammary Tumor Virus, Mouse, Genes, Bacterial, Mutation, Virus Activation, ddc:570

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